RITA1 antibody (C-Term)

Catalog No. ABIN5514467

The Rabbit Polyclonal anti-RITA1 antibody (ABIN5514467) specifically detects RITA1 in WB. The antibody is reactive with Human samples.

Quick Overview for RITA1 antibody (C-Term) (ABIN5514467)

Target: RITA1 (Tyrosine-Based Site-Specific Recombinase (Recombinase Triad in CMGI-2) (RITA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RITA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RITA1 Antibody

Binding Specificity: C-Term

Sequence: TNGPQDLRPS TSGVTFRSPL VTSRARSVSI SVPSTPRRGG ATQKPKPPWK

Characteristics: This is a rabbit polyclonal antibody against RITA1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RITA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RITA1

Target: RITA1 (Tyrosine-Based Site-Specific Recombinase (Recombinase Triad in CMGI-2) (RITA1))

Alternative Name: RITA1

Background: RITA1 is a tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. It shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. And it may play a role in neurogenesis.

Alias Symbols: C12orf52, RITA, PSEC0043

Protein Size: 269

Gene ID: 84934

NCBI Accession: XP_005254029

UniProt: Q96K30