Opiorphin Prepropeptide (OPRPN) (N-Term) antibody

Catalog No. ABIN5514594

This Rabbit Polyclonal antibody specifically detects Opiorphin Prepropeptide in WB. It exhibits reactivity toward Human.

Quick Overview for Opiorphin Prepropeptide (OPRPN) (N-Term) antibody (ABIN5514594)

Target: Opiorphin Prepropeptide (OPRPN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details

Binding Specificity: N-Term

Purpose: OPRPN Antibody - N-terminal region

Sequence: SFNYTTPDYG HYDDKDTLDL NTPVDKTSNT LRVPDILALV IFAVVFLVGV

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human C5AR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP77605-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Opiorphin Prepropeptide (OPRPN)

Alternative Name: OPRPN

Background:

Background Information: This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants.

Gene Name: opiorphin prepropeptide

Alternative Symbols: BPLP, PRL1, PROL1, opiorphin

Protein Name: opiorphin prepropeptide

Molecular Weight: 38 kDa

Gene ID: 58503

NCBI Accession: NP_001727

UniProt: P21730