CNOT8 antibody (C-Term)

Catalog No. ABIN5514645

This Rabbit Polyclonal antibody specifically detects CNOT8 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for CNOT8 antibody (C-Term) (ABIN5514645)

Target: CNOT8 (CCR4-NOT Transcription Complex, Subunit 8 (CNOT8))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CNOT8 Antibody

Binding Specificity: C-Term

Sequence: DSRLPEEEHE FFHILNLFFP SIYDVKYLMK SCKNLKGGLQ EVADQLDLQR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against CNOT8. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CNOT8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CNOT8

Target: CNOT8 (CCR4-NOT Transcription Complex, Subunit 8 (CNOT8))

Alternative Name: CNOT8

Background: CNOT8 has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. It associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Alias Symbols: CNOT8, CALIF, POP2,

Protein Size: 292

Gene ID: 9337

UniProt: Q9UFF9