CKMT1A antibody (C-Term)

Catalog No. ABIN5514690

This Rabbit Polyclonal antibody specifically detects CKMT1A in WB. It exhibits reactivity toward Human.

Quick Overview for CKMT1A antibody (C-Term) (ABIN5514690)

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKMT1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CKMT1A Antibody

Binding Specificity: C-Term

Sequence: QKRGTGGVDT AATGGVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CKMT1A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CKMT1A

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Alternative Name: CKMT1A

Background: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Alias Symbols: CKMT1, U-MtCK, mia-CK

Protein Interaction Partner: UBC, MDM2, SUZ12, gag-pol, CUL3, ASB9, VDAC1, SLC25A5, CKMT1A,

Protein Size: 417

Gene ID: 548596

NCBI Accession: NM_001015001, NP_001015001

UniProt: P12532