DRD3 antibody (N-Term)

Catalog No. ABIN5514728

The Rabbit Polyclonal anti-DRD3 antibody (ABIN5514728) specifically detects DRD3 in WB. The antibody is reactive with Human samples.

Quick Overview for DRD3 antibody (N-Term) (ABIN5514728)

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DRD3 Antibody

Binding Specificity: N-Term

Purpose: DRD3 Antibody - N-terminal region

Sequence: ASLSQLSSHL NYTCGAENST GASQARPHAY YALSYCALIL AIVFGNGLVC

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DRD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP80755-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DRD3

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Alternative Name: DRD3

Background:

Background Information: This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

Gene Name: dopamine receptor D3

Alternative Symbols: D3DR, ETM1, FET1

Protein Name: D(3) dopamine receptor

Molecular Weight: 44 kDa

Gene ID: 1814

NCBI Accession: NP_000787

UniProt: P35462

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity