LZTS1 antibody (N-Term)

Catalog No. ABIN5514757

Product Details anti-LZTS1 Antibody

Target: LZTS1 (Leucine Zipper, Putative Tumor Suppressor 1 (LZTS1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LZTS1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG KSEDFFYIKV SQKARGSHHP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 79%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against LZTS1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human LZTS1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LZTS1

Target: LZTS1 (Leucine Zipper, Putative Tumor Suppressor 1 (LZTS1))

Alternative Name: LZTS1 (LZTS1 Products)

Synonyms: F37 antibody, FEZ1 antibody, Psdzip70 antibody, LZTS1 antibody, f37 antibody, fez1 antibody, leucine zipper tumor suppressor 1 antibody, leucine zipper, putative tumor suppressor 1 antibody, LZTS1 antibody, Lzts1 antibody, lzts1 antibody

Background: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.

Alias Symbols: LZTS1, FEZ1,

Protein Interaction Partner: EEF1G, CDC25C, CDK1,

Protein Size: 596

Gene ID: 11178

NCBI Accession: XP_005273451

UniProt: Q9Y250

Pathways: Synaptic Membrane