ALPL antibody (N-Term)

Catalog No. ABIN5514802

The Rabbit Polyclonal anti-ALPL antibody is suitable to detect ALPL in samples from Human. It has been validated for WB.

Quick Overview for ALPL antibody (N-Term) (ABIN5514802)

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALPL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALPL Antibody

Binding Specificity: N-Term

Purpose: ALPL Antibody - N-terminal region

Sequence: FLVLAIGTCL TNSLVPEKEK DPKYWRDQAQ ETLKYALELQ KLNTNVAKNV

Characteristics: This is a rabbit polyclonal antibody against PPBT. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PPBT

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75902-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ALPL

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Alternative Name: ALPL

Background:

Background Information: This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.

Gene Name: alkaline phosphatase, biomineralization associated

Alternative Symbols: HOPS, TNAP, TNALP, APTNAP, TNSALP, AP-TNAP

Protein Name: alkaline phosphatase, tissue-nonspecific isozyme

Molecular Weight: 57kDa

Gene ID: 249

NCBI Accession: XP_006710609

UniProt: P05186