Growth Hormone Receptor antibody (N-Term)

Catalog No. ABIN5514835

The Rabbit Polyclonal anti-Growth Hormone Receptor antibody has been validated for WB. It is suitable to detect Growth Hormone Receptor in samples from Human and Horse.

Quick Overview for Growth Hormone Receptor antibody (N-Term) (ABIN5514835)

Target: Growth Hormone Receptor (GHR)

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Growth Hormone Receptor Antibody

Binding Specificity: N-Term

Sequence: LLTLALAGSS DAFSGSEATA AILSRAPWSL QSVNPGLKTN SSKEPKFTKC

Predicted Reactivity: Horse: 83%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GHR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: GHR

Background: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

Alias Symbols: GHR,

Protein Interaction Partner: FBXW11, JAK2, GHR, GH1, BTRC, UBC, SKP1, SOCS2, STUB1, PTPRH, PTPRB, PTPN13, PTPN9, PTPN3, PTPN2, PTPN1, DUSP7, NCOA6, STAT5B, SOCS3, SOCS1, SGTA, CISH, GRB10, STAT5A, AP2A1, SHC1, TYK2, PTPN6, PTPN11, PRLR, PIK3R1, JAK1, IRS1, GH2, GRB2, STAT3, PLCG1,

Protein Size: 297

Gene ID: 2690

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus