HRH1 antibody (C-Term)

Catalog No. ABIN5514867

This Rabbit Polyclonal antibody specifically detects HRH1 in WB. It exhibits reactivity toward Human.

Quick Overview for HRH1 antibody (C-Term) (ABIN5514867)

Target: HRH1 (Histamine Receptor H1 (HRH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HRH1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HRH1 Antibody

Binding Specificity: C-Term

Sequence: SSWPSPTEPS SKSGNLRHLH ILIGTSVVKI PFTILLFFLL HRWCSNKKKC

Predicted Reactivity: Human: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HRH1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HRH1

Target: HRH1 (Histamine Receptor H1 (HRH1))

Alternative Name: HRH1

Background: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alias Symbols: H1R, H1-R, HH1R, hisH1

Protein Interaction Partner: UBC,

Protein Size: 487

Gene ID: 3269

NCBI Accession: NM_000861, NP_000852

UniProt: P35367

Pathways: Regulation of Carbohydrate Metabolic Process