ITM2B antibody (N-Term)

Catalog No. ABIN5514896

This anti-ITM2B antibody is a Rabbit Polyclonal antibody detecting ITM2B in WB. Suitable for Human.

Quick Overview for ITM2B antibody (N-Term) (ABIN5514896)

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ITM2B Antibody

Binding Specificity: N-Term

Sequence: FNSALAQKEA KKDEPKSGEE ALIIPPDAVA VDCKDPDDVV PVGQRRAWCW

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ITM2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 29 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Alternative Name: ITM2B

Background: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Alias Symbols: BRI, FBD, ABRI, BRI2, E25B, E3-16, RDGCA, imBRI2, BRICD2B

Protein Size: 266

Gene ID: 9445

NCBI Accession: NM_021999, NP_068839

UniProt: Q9Y287