PTPMT1 antibody (N-Term)

Catalog No. ABIN5515057

The Rabbit Polyclonal anti-PTPMT1 antibody is suitable to detect PTPMT1 in samples from Human. It has been validated for WB.

Quick Overview for PTPMT1 antibody (N-Term) (ABIN5515057)

Target: PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPMT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PTPMT1 Antibody

Binding Specificity: N-Term

Purpose: PTPMT1 Antibody - N-terminal region

Sequence: LFYPTLLYTL FRGKVPGRAH RDWYHRIDPT VLLGALPLRS LTRQLVQDEN

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTPMT1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP79956-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTPMT1

Target: PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))

Alternative Name: PTPMT1

Background:

Background Information: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).

Gene Name: protein tyrosine phosphatase, mitochondrial 1

Alternative Symbols: MOSP, PLIP, DUSP23, PNAS-129

Protein Name: phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Molecular Weight: 23 kDa

Gene ID: 114971

NCBI Accession: NP_001137456

UniProt: Q8WUK0

Pathways: Inositol Metabolic Process