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ROBO3 antibody (C-Term)

ROBO3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5515113
  • Target See all ROBO3 Antibodies
    ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
    Binding Specificity
    • 3
    • 3
    • 2
    • 1
    C-Term
    Reactivity
    • 20
    • 5
    • 3
    • 3
    • 3
    • 1
    Human
    Host
    • 15
    • 4
    • 4
    Rabbit
    Clonality
    • 21
    • 2
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ROBO3 antibody is un-conjugated
    Application
    • 14
    • 13
    • 5
    • 1
    Western Blotting (WB)
    Sequence
    HPSRSPSAQE PRGSCCPSNP DPDDRYYNEA GISLYLAQTA RGTAAPGEGP
    Characteristics
    This is a rabbit polyclonal antibody against ROBO3. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human ROBO3
    Top Product
    Discover our top product ROBO3 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ROBO3 (Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
    Alternative Name
    ROBO3 (ROBO3 Products)
    Synonyms
    HGPPS antibody, HGPS antibody, RBIG1 antibody, RIG1 antibody, CG14345 antibody, CT17158 antibody, Robo-3 antibody, Robo3 antibody, dRobo-3 antibody, DmelCG5423 antibody, CG5423 antibody, ROBO3 antibody, robo3 antibody, DKFZp468G0223 antibody, Rbig1 antibody, Rig-1 antibody, Rig1 antibody, Robo3a antibody, Robo3b antibody, cb503 antibody, roundabout guidance receptor 3 antibody, roundabout 3 antibody, robo3 antibody, roundabout guidance receptor 3 L homeolog antibody, roundabout, axon guidance receptor, homolog 3 (Drosophila) antibody, ROBO3 antibody, robo3 antibody, Robo3 antibody, LOC658818 antibody, robo3.L antibody
    Background
    This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.

    Alias Symbols: ROBO3,

    Protein Interaction Partner: CCDC57, LNX1, RBMX, MTUS2, Zswim8, APOA1, NEDD4L, UBC,

    Protein Size: 1386
    Gene ID
    64221
    NCBI Accession
    NP_071765
    UniProt
    Q96MS0
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