Azurocidin antibody (Middle Region)

Catalog No. ABIN5515391

The Rabbit Polyclonal anti-Azurocidin antibody (ABIN5515391) specifically detects Azurocidin in WB. The antibody is reactive with Human, Cow, Horse and Pig samples.

Quick Overview for Azurocidin antibody (Middle Region) (ABIN5515391)

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Reactivity: Human, Cow, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Azurocidin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Azurocidin Antibody

Binding Specificity: Middle Region

Purpose: AZU1 Antibody - middle region

Sequence: QSQNPGVSTV VLGAYDLRRR ERQSRQTFSI SSMSENGYDP QQNLNDLMLL

Predicted Reactivity: Cow: 100%, Horse: 75%, Human: 100%, Pig: 85%

Characteristics: This is a rabbit polyclonal antibody against AZU1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AZU1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP73078-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Azurocidin

Target: Azurocidin (AZU1) (Azurocidin 1 (AZU1))

Alternative Name: AZU1

Background:

Background Information: Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Gene Name: azurocidin 1

Alternative Symbols: AZU, HBP, NAZC, hHBP, AZAMP, CAP37, HUMAZUR

Protein Name: azurocidin

Molecular Weight: 24kDa

Gene ID: 566

NCBI Accession: NP_001691

UniProt: P20160