CCAR1 antibody (C-Term)

Catalog No. ABIN5515401

This Rabbit Polyclonal antibody specifically detects CCAR1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Pig and Guinea Pig.

Quick Overview for CCAR1 antibody (C-Term) (ABIN5515401)

Target: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Cow, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CCAR1 Antibody

Binding Specificity: C-Term

Sequence: YDPMEAEEAE DEEDDRDEEE MTKRDDKRDI NRYCKERPSK DKEKEKTQMI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CCAR1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CCAR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CCAR1

Target: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Alternative Name: CCAR1

Background: CCAR1 associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. It is recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. It also functions as a p53 coactivator. It may thus play an important role in transcriptional regulation (By similarity). It may be involved in apoptosis signaling in the presence of the reinoid CD437. It apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. And it plays a role in cell cycle progression and/or cell proliferation.

Alias Symbols: CARP1, DIS

Protein Interaction Partner: PIH1D3, GOLGA2, SUMO2, SUMO3, UBC, TP53, MDM2, U2AF2, CHERP, UBL4A, RBM10, RNF113A, HNRNPK, SMURF1, BARD1, SIRT7, SF3A2, Kif23, FYCO1, CASP10, SFN, YWHAQ,

Protein Size: 1150

Gene ID: 55749

NCBI Accession: NP_060707

UniProt: Q8IX12