RTEL1 antibody (C-Term)

Catalog No. ABIN5515690

The Rabbit Polyclonal anti-RTEL1 antibody is suitable to detect RTEL1 in samples from Human. It has been validated for WB.

Quick Overview for RTEL1 antibody (C-Term) (ABIN5515690)

Target: RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RTEL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RTEL1 Antibody

Binding Specificity: C-Term

Purpose: RTEL1 Antibody - C-terminal region

Sequence: QGRPHLSPRP PPTGDPGSQP QWGSGVPRAG KQGQHAVSAY LADARRALGS

Characteristics: This is a rabbit polyclonal antibody against RTEL1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RTEL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74195-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for RTEL1

Target: RTEL1 (Regulator of Telomere Elongation Helicase 1 (RTEL1))

Alternative Name: RTEL1

Background:

Background Information: This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative Symbols: NHL, RTEL, DKCA4, DKCB5, PFBMFT3, C20orf41

Molecular Weight: 109kDa

Gene ID: 51750

UniProt: Q9NZ71