Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: AP1S2, DC22,
Protein Interaction Partner: AP1G1, EGFR, AP1M1, AP1B1, ELAVL1, UBC, GGA3, AP1G2,
Protein Size: 157