DAXX antibody (N-Term)

Catalog No. ABIN5515954

The Rabbit Polyclonal anti-DAXX antibody has been validated for WB. It is suitable to detect DAXX in samples from Human.

Quick Overview for DAXX antibody (N-Term) (ABIN5515954)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DAXX Antibody

Binding Specificity: N-Term

Sequence: KLNLAPAATT SNEPSGNNPP THLSLDPTNA ENTASQSPRT RGSRRQIQRL

Characteristics: This is a rabbit polyclonal antibody against DAXX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAXX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: DAXX

Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Alias Symbols: Name=DAXX

Protein Interaction Partner: FAM9B, SSX2IP, SUMO1, UBE2I, UBC, GOLGA2, CARD9, PBXIP1, CDCA7L, NECAB2, RASSF1, PML, MDM2, H3F3A, DNMT1, TP53, ATRX, CARM1, PRMT1, WHSC1L1, CUL3, SPOP, HIPK2, PDCD4, DNMT3A, USP7, UBB, RELB, DAXX, CREB1, CBS, ATM, HIST1H4F, HIST1H3C, TRAF3, HIST4H4, BTBD

Protein Size: 740

Gene ID: 1616

NCBI Accession: NP_001341

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway