DEFA5 antibody (N-Term)

Catalog No. ABIN5515995

This Rabbit Polyclonal antibody specifically detects DEFA5 in WB. It exhibits reactivity toward Human.

Quick Overview for DEFA5 antibody (N-Term) (ABIN5515995)

Target: DEFA5 (Defensin, alpha 5, Paneth Cell-Specific (DEFA5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEFA5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DEFA5 Antibody

Binding Specificity: N-Term

Purpose: DEFA5 Antibody - N-terminal region

Sequence: QAQAESLQER ADEATTQKQS GEDNQDLAIS FAGNGLSALR TSGSQARATC

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against DEF5. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human DEF5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52392-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for DEFA5

Target: DEFA5 (Defensin, alpha 5, Paneth Cell-Specific (DEFA5))

Alternative Name: DEFA5

Background:

Background Information: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene Name: defensin alpha 5

Alternative Symbols: DEF5, HD-5

Protein Name: defensin-5

Molecular Weight: 10kDa

Gene ID: 1670

NCBI Accession: NP_066290

UniProt: Q01523