GAMT antibody (N-Term)

Catalog No. ABIN5516042

The Rabbit Polyclonal anti-GAMT antibody (ABIN5516042) specifically detects GAMT in WB. The antibody is reactive with Human, Rat, Mouse, Zebrafish (Danio rerio), Guinea Pig, Cow, Dog and Horse samples.

Quick Overview for GAMT antibody (N-Term) (ABIN5516042)

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Reactivity: Human, Rat, Mouse, Zebrafish (Danio rerio), Guinea Pig, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAMT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GAMT Antibody

Binding Specificity: N-Term

Purpose: GAMT Antibody - N-terminal region

Sequence: IPLKGLWEDV APTLPDGHFD GILYDTYPLS EETWHTHQFN FIKNHAFRLL

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against GAMT. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GAMT

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41685-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GAMT

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Alternative Name: GAMT

Background:

Background Information: The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13.

Gene Name: guanidinoacetate N-methyltransferase

Alternative Symbols: PIG2, CCDS2, TP53I2, HEL-S-20

Protein Name: Guanidinoacetate N-methyltransferase

Molecular Weight: 29kDa

Gene ID: 2593

NCBI Accession: NP_620279

UniProt: Q14353