LITAF antibody (N-Term)

Catalog No. ABIN5516083

The Rabbit Polyclonal anti-LITAF antibody is suitable to detect LITAF in samples from Human. It has been validated for WB.

Quick Overview for LITAF antibody (N-Term) (ABIN5516083)

Target: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LITAF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LITAF Antibody

Binding Specificity: N-Term

Sequence: PSYEETVAVN SYYPTPPAPM PGPTTGLVTG PDGKGMNPPS YYTQPAPIPN

Characteristics: This is a rabbit polyclonal antibody against LITAF. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human LITAF

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for LITAF

Target: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Alternative Name: LITAF

Background: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.

Alias Symbols: LITAF, PIG7, SIMPLE,

Protein Interaction Partner: REEP6, UBQLN1, STAM2, CALCOCO2, BAG3, HGS, UBC, STAT6, ATXN1, ITCH, TSG101, NEDD4, ELAVL1, RADIL, SMAD2, COMT,

Protein Size: 228

Gene ID: 9516

Pathways: Cellular Response to Molecule of Bacterial Origin