CKMT1B antibody (N-Term)

Catalog No. ABIN5516114

The Rabbit Polyclonal anti-CKMT1B antibody (ABIN5516114) specifically detects CKMT1B in WB. The antibody is reactive with Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse and Zebrafish (Danio rerio) samples.

Quick Overview for CKMT1B antibody (N-Term) (ABIN5516114)

Target: CKMT1B (Creatine Kinase, Mitochondrial 1B (CKMT1B))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKMT1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CKMT1B Antibody

Binding Specificity: N-Term

Sequence: TVGMVAGDEE TYEVFADLFD PVIQERHNGY DPRTMKHTTD LDASKIRSGY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against CKMT1B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CKMT1B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CKMT1B

Target: CKMT1B (Creatine Kinase, Mitochondrial 1B (CKMT1B))

Alternative Name: CKMT1B

Background: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Protein Interaction Partner: UBC, ASB9, BMI1, HECW2, IQCB1, gag-pol, IGBP1, CUL3, CALM1, HDAC5,

Protein Size: 417

Gene ID: 1159

NCBI Accession: XP_005254554

UniProt: P12532