SMC6 antibody (N-Term)

Catalog No. ABIN5516172

This Rabbit Polyclonal antibody specifically detects SMC6 in WB. It exhibits reactivity toward Human.

Quick Overview for SMC6 antibody (N-Term) (ABIN5516172)

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMC6 Antibody

Binding Specificity: N-Term

Purpose: SMC6 Antibody - N-terminal region

Sequence: MAKRKEENFS SPKNAKRPRQ EELEDFDKDG DEDECKGTTL TAAEVGIIES

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMC6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP81178-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMC6

Target: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Alternative Name: SMC6

Background:

Background Information: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.

Gene Name: structural maintenance of chromosomes 6

Alternative Symbols: SMC-6, hSMC6, SMC6L1

Protein Name: structural maintenance of chromosomes protein 6

Molecular Weight: 120 kDa

Gene ID: 79677

NCBI Accession: NP_001135758

UniProt: Q96SB8