COPS6 antibody (C-Term)

Catalog No. ABIN5516175

This Rabbit Polyclonal antibody specifically detects COPS6 in WB. It exhibits reactivity toward Human.

Quick Overview for COPS6 antibody (C-Term) (ABIN5516175)

Target: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COPS6 Antibody

Binding Specificity: C-Term

Sequence: LILEYVKASE AGEVPFNHEI LREAYALCHC LPVLSTDKFK TDFYDQCNDV

Characteristics: This is a rabbit polyclonal antibody against COPS6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human COPS6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COPS6

Target: COPS6 (COP9 Signalosome Complex Subunit 6 (COPS6))

Alternative Name: COPS6

Background: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

Alias Symbols: Name=COPS6,

Protein Interaction Partner: NEDD8, CUL1, UBC, COPS5, GPS1, SUMO1, POP7, COPS7B, COPS7A, CUL4B, USP7, COPS4, FBXO6, FBXW4, IGHV3OR15-7, vpr, TP63, RFWD2, SFN, IRF5, COPS8, COPS2, COPS3, DDB2, DDB1, ERCC8, TOR1AIP2, LRR1, RBX1, VPRBP, LRRC14, CUL2, CUL3, CUL4A, CUL5, TCEB2, TCEB1, SKP

Protein Size: 327

Gene ID: 10980

NCBI Accession: NP_006824

UniProt: Q7L5N1

Pathways: Cell Division Cycle