HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (C-Term) antibody

Catalog No. ABIN5516370

This Rabbit Polyclonal antibody specifically detects HERV-FRD Provirus Ancestral Env Polyprotein in WB. It exhibits reactivity toward Human.

Quick Overview for HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd) (C-Term) antibody (ABIN5516370)

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: C-Term

Purpose: ERVFRD-1 Antibody - C-terminal region

Sequence: PLVSLLLLLL FGPCLLNLIT QFVSSRLQAI KLQTNLSAGR HPRNIQESPF

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ERVFRD-1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ERVFRD-1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP56009-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: HERV-FRD Provirus Ancestral Env Polyprotein (Herv-frd)

Alternative Name: ERVFRD-1

Background:

Background Information: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

Gene Name: endogenous retrovirus group FRD, member 1

Alternative Symbols: envFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD

Protein Name: HERV-FRD_6p24.1 provirus ancestral Env polyprotein

Molecular Weight: 59kDa

Gene ID: 405754

NCBI Accession: NP_997465

UniProt: P60508