ARVCF antibody (C-Term)

Catalog No. ABIN5516447

The Rabbit Polyclonal anti-ARVCF antibody (ABIN5516447) specifically detects ARVCF in WB. The antibody is reactive with Human samples.

Quick Overview for ARVCF antibody (C-Term) (ABIN5516447)

Target: ARVCF (Armadillo Repeat Gene Deleted in Velocardiofacial Syndrome (ARVCF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARVCF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ARVCF Antibody

Binding Specificity: C-Term

Sequence: GPDGYSTVDR RERRPRGASS AGEASEKEPL KLDPSRKAPP PGPSRPAVRL

Characteristics: This is a rabbit polyclonal antibody against ARVCF. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ARVCF

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ARVCF

Target: ARVCF (Armadillo Repeat Gene Deleted in Velocardiofacial Syndrome (ARVCF))

Alternative Name: ARVCF

Background: Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein.

Alias Symbols: Name=ARVCF,

Protein Interaction Partner: ERBB2IP, UBC, LNX1, TJP1, CDH1, CDH2, CDH15,

Protein Size: 962

Gene ID: 421

NCBI Accession: NP_001661

UniProt: O00192