MAPK8IP1 antibody (N-Term)

Catalog No. ABIN5516519

Product Details anti-MAPK8IP1 Antibody

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK8IP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GSGDTYRPKR PTTLNLFPQV PRSQDTLNNN SLGKKHSWQD RVSRSSSPLK

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAPK8IP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 29 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPK8IP1

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Alternative Name: MAPK8IP1 (MAPK8IP1 Products)

Synonyms: IB1 antibody, JIP-1 antibody, Jip1 antibody, Prkm8ip antibody, Skip antibody, mjip-2a antibody, JIP1 antibody, Jip-1 antibody, Mapk8ip antibody, PRKM8IP antibody, mitogen-activated protein kinase 8 interacting protein 1 antibody, MAPK8IP1 antibody, Mapk8ip1 antibody

Background: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Alias Symbols: IB1, JIP1, JIP-1, PRKM8IP

Protein Size: 711

Gene ID: 9479

NCBI Accession: NM_005456, NP_005447

UniProt: Q9UQF2