SLC16A2/MCT8 antibody (N-Term)

Catalog No. ABIN5516550

This Rabbit Polyclonal antibody specifically detects SLC16A2/MCT8 in WB. It exhibits reactivity toward Human.

Quick Overview for SLC16A2/MCT8 antibody (N-Term) (ABIN5516550)

Target: SLC16A2/MCT8 (SLC16A2) (Solute Carrier Family 16 Member 2 (SLC16A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC16A2/MCT8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SLC16A2/MCT8 Antibody

Binding Specificity: N-Term

Purpose: SLC16A2 Antibody - N-terminal region

Sequence: EPEPVPVPPP EPQPEPQPLP DPAPLPELEF ESERVHEPEP TPTVETRGTA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SLC16A2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP80952-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SLC16A2/MCT8

Target: SLC16A2/MCT8 (SLC16A2) (Solute Carrier Family 16 Member 2 (SLC16A2))

Alternative Name: SLC16A2

Background:

Background Information: This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome.

Gene Name: solute carrier family 16, member 2 (thyroid hormone transporter)

Alternative Symbols: AHDS, MCT7, MCT8, XPCT, MCT 7, MCT 8, MRX22, DXS128, DXS128E

Protein Name: monocarboxylate transporter 8

Molecular Weight: 59 kDa

Gene ID: 6567

NCBI Accession: NP_006508

UniProt: P36021

Pathways: Hormone Transport