HLCS antibody (C-Term)

Catalog No. ABIN5516597

The Rabbit Polyclonal anti-HLCS antibody (ABIN5516597) specifically detects HLCS in WB. The antibody is reactive with Human samples.

Quick Overview for HLCS antibody (C-Term) (ABIN5516597)

Target: HLCS (Biotin-Protein Ligase (HLCS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLCS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HLCS Antibody

Binding Specificity: C-Term

Purpose: HLCS Antibody - C-terminal region

Sequence: MSVAVVEAVR SIPEYQDINL RVKWPNDIYY SDLMKIGGVL VNSTLMGETF

Characteristics: This is a rabbit polyclonal antibody against BPL1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen for Anti-HLCS antibody is: synthetic peptide directed towards the C-terminal region of Human BPL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74943-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HLCS

Target: HLCS (Biotin-Protein Ligase (HLCS))

Alternative Name: HLCS

Background:

Background Information: This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

Alternative Symbols: HCS

Molecular Weight: 79 kDa

Gene ID: 3141

NCBI Accession: XP_006724059

UniProt: P50747