KRIT1 antibody (C-Term)

Catalog No. ABIN5516696

The Rabbit Polyclonal anti-KRIT1 antibody (ABIN5516696) specifically detects KRIT1 in WB. The antibody is reactive with Human samples.

Quick Overview for KRIT1 antibody (C-Term) (ABIN5516696)

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRIT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KRIT1 Antibody

Binding Specificity: C-Term

Purpose: KRIT1 Antibody - C-terminal region

Sequence: LLQIVYGNYE SKKHKQGFLN EENLKSIVPV TKLKSKAPHW TNRILHEYKN

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KRIT1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP74923-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KRIT1

Target: KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))

Alternative Name: KRIT1

Background:

Background Information: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Gene Name: KRIT1, ankyrin repeat containing

Alternative Symbols: CAM, CCM1

Protein Name: krev interaction trapped protein 1

Molecular Weight: 58 kDa

Gene ID: 889

UniProt: O00522

Pathways: Cell RedoxHomeostasis