COQ6 antibody (N-Term)

Catalog No. ABIN5517062

The Rabbit Polyclonal anti-COQ6 antibody (ABIN5517062) specifically detects COQ6 in WB. The antibody is reactive with Human, Rat, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse and Saccharomyces cerevisiae samples.

Quick Overview for COQ6 antibody (N-Term) (ABIN5517062)

Target: COQ6 (Coenzyme Q6, Monooxygenase (COQ6))

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COQ6 Antibody

Binding Specificity: N-Term

Purpose: COQ6 Antibody - N-terminal region

Sequence: ILLLEAGPKK VLEKLSETYS NRVSSISPGS ATLLSSFGAW DHICNMRYRA

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Yeast: 80%

Characteristics: This is a rabbit polyclonal antibody against COQ6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human COQ6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64161-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for COQ6

Target: COQ6 (Coenzyme Q6, Monooxygenase (COQ6))

Alternative Name: COQ6

Background:

Background Information: The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative Symbols: CGI10, CGI-10, COQ10D6

Protein Name: Ubiquinone biosynthesis monooxygenase COQ6

Molecular Weight: 48kDa

Gene ID: 51004

NCBI Accession: NP_872286

UniProt: Q9Y2Z9