TRIM63 antibody (C-Term)

Catalog No. ABIN5517180

This Rabbit Polyclonal antibody specifically detects TRIM63 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig and Rabbit.

Quick Overview for TRIM63 antibody (C-Term) (ABIN5517180)

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM63 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIM63 Antibody

Binding Specificity: C-Term

Purpose: TRIM63 Antibody - C-terminal region

Sequence: TIITQLEDSR RVTKENSHQV KEELSQKFDT LYAILDEKKS ELLQRITQEQ

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TRIM63. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TRIM63

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43364-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM63

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Alternative Name: TRIM63

Background:

Background Information: This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.

Gene Name: tripartite motif containing 63, E3 ubiquitin protein ligase

Alternative Symbols: IRF, SMRZ, MURF1, MURF2, RNF28

Protein Name: E3 ubiquitin-protein ligase TRIM63

Molecular Weight: 38kDa

Gene ID: 84676

NCBI Accession: NP_115977

UniProt: Q969Q1