GAR1 antibody (N-Term)

Catalog No. ABIN5517216

This Rabbit Polyclonal antibody specifically detects GAR1 in WB. It exhibits reactivity toward Human.

Quick Overview for GAR1 antibody (N-Term) (ABIN5517216)

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GAR1 Antibody

Binding Specificity: N-Term

Purpose: GAR1 Antibody - N-terminal region

Sequence: GRGGFGRGGG RGGFNKGQDQ GPPERVVLLG EFLHPCEDDI VCKCTTDENK

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GAR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75607-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GAR1

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Alternative Name: GAR1

Background:

Background Information: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.

Gene Name: GAR1 ribonucleoprotein

Alternative Symbols: NOLA1

Protein Name: H/ACA ribonucleoprotein complex subunit 1

Molecular Weight: 22 kDa

Gene ID: 54433

NCBI Accession: NP_061856

UniProt: Q9NY12