PPP1R12B antibody (Middle Region)

Catalog No. ABIN5517282

This Rabbit Polyclonal antibody specifically detects PPP1R12B in WB. It exhibits reactivity toward Human.

Quick Overview for PPP1R12B antibody (Middle Region) (ABIN5517282)

Target: PPP1R12B (Protein Phosphatase 1, Regulatory Subunit 12B (PPP1R12B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R12B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PPP1R12B Antibody

Binding Specificity: Middle Region

Sequence: FNKPEEPKDE SPSSWRLGLR KTGSHNMLSE VANSREPIRD RGSSIYRSSS

Characteristics: This is a rabbit polyclonal antibody against MYPT2. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen for Anti-PPP1R12B antibody is: synthetic peptide directed towards the Middle region of Human MYPT2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PPP1R12B

Target: PPP1R12B (Protein Phosphatase 1, Regulatory Subunit 12B (PPP1R12B))

Alternative Name: PPP1R12B

Background: Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome.

Alias Symbols: MYPT2, PP1bp55

Protein Size: 982

Gene ID: 4660

UniProt: O60237

Pathways: M Phase