NFKBIL2 antibody (C-Term)

Catalog No. ABIN5517400

The Rabbit Polyclonal anti-NFKBIL2 antibody is suitable to detect NFKBIL2 in samples from Human. It has been validated for WB.

Quick Overview for NFKBIL2 antibody (C-Term) (ABIN5517400)

Target: NFKBIL2 (Tonsoku-Like, DNA Repair Protein (NFKBIL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKBIL2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NFKBIL2 Antibody

Binding Specificity: C-Term

Sequence: LTRSRRPRPR GTGDNRRPSS TSGSDSEESR PRARAKQVRL TCMQSCSAPV

Characteristics: This is a rabbit polyclonal antibody against TONSL. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TONSL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NFKBIL2

Target: NFKBIL2 (Tonsoku-Like, DNA Repair Protein (NFKBIL2))

Alternative Name: TONSL

Background: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.

Alias Symbols: TONSL, IKBR, NFKBIL2,

Protein Interaction Partner: HIST3H3, MCM6, MCM2, MMS22L, ASF1B, ASF1A, UBC, MYC, MAU2, SLC25A5, SUPT16H, SUGT1, AIFM1, HIST1H2BL, XRCC5, SSRP1, SLC25A3, TONSL, MCM4, HIST1H2AE, HIST1H1B, HIST1H1C, XRCC6, GSK3B, MCM7, MCM5, MCM3, EWSR1,

Protein Size: 1378

Gene ID: 4796

NCBI Accession: NP_038460

UniProt: Q96HA7

Pathways: Maintenance of Protein Location