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RASGRP1 antibody (Middle Region)
RASGRP1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-RASGRP1 Antibody
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Target
See all RASGRP1 Antibodies
RASGRP1
(RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
Binding Specificity
All epitopes for RASGRP1 antibodies
Middle Region
Reactivity
All reactivities for RASGRP1 antibodies
Human
Host
All hosts for RASGRP1 antibodies
Rabbit
Clonality
All clonalities for RASGRP1 antibodies
Polyclonal
Conjugate
All conjugates for RASGRP1 antibodies
This RASGRP1 antibody is un-conjugated
Application
All applications for RASGRP1 antibodies
Western Blotting (WB)
Sequence
GLCHSSISRL KETSSHVPHE INKVLGEMTE LLSSSRNYDN YRRAYGECTD
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human RASGRP1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for RASGRP1
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Target
RASGRP1
(RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
Alternative Name
RASGRP1 (RASGRP1 Products )
Synonyms
Rasgrp antibody, CALDAG-GEFI antibody, CALDAG-GEFII antibody, RASGRP antibody, V antibody, hRasGRP1 antibody, RAS guanyl releasing protein 1 antibody, Rasgrp1 antibody, RASGRP1 antibody
Background
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). Alias Symbols: V, RASGRP, hRasGRP1, CALDAG-GEFI, CALDAG-GEFII Protein Size: 797
Gene ID
10125
NCBI Accession
NM_001128602 , NP_001122074
UniProt
O95267
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway
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