STIL antibody (N-Term)

Catalog No. ABIN5517883

The Rabbit Polyclonal anti-STIL antibody is suitable to detect STIL in samples from Human. It has been validated for WB.

Quick Overview for STIL antibody (N-Term) (ABIN5517883)

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-STIL Antibody

Binding Specificity: N-Term

Purpose: STIL Antibody - N-terminal region

Sequence: QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI QPSVPELSLV

Characteristics: This is a rabbit polyclonal antibody against STIL. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human STIL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75124-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for STIL

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Alternative Name: STIL

Background:

Background Information: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Symbols: SIL, MCPH7

Molecular Weight: 141 kDa

Gene ID: 6491

UniProt: Q15468

Pathways: Tube Formation