C16orf57 antibody (N-Term)

Catalog No. ABIN5517969

Product Details anti-C16orf57 Antibody

Target: C16orf57 (USB1) (U6 SnRNA Biogenesis 1 (USB1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C16orf57 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LVGYSSSGSE DESEDGMRTR PGDGSHRRGQ SPLPRQRFPV PDSVLNMFPG

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human C16ORF57

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for C16orf57

Target: C16orf57 (USB1) (U6 SnRNA Biogenesis 1 (USB1))

Alternative Name: C16ORF57 (USB1 Products)

Synonyms: C16orf57 antibody, HVSL1 antibody, Mpn1 antibody, PN antibody, hUsb1 antibody, C18H16orf57 antibody, AA960436 antibody, RGD1305215 antibody, c16orf57 antibody, C2H16orf57 antibody, zgc:91896 antibody, U6 snRNA biogenesis phosphodiesterase 1 antibody, U6 snRNA biogenesis 1 antibody, U6 snRNA biogenesis phosphodiesterase 1 L homeolog antibody, USB1 antibody, Usb1 antibody, usb1.L antibody, usb1 antibody

Background: This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alias Symbols: PN, Mpn1, HVSL1, hUsb1, C16orf57

Protein Size: 186

Gene ID: 79650

NCBI Accession: NM_001195302, NP_001182231