Proteoglycan 4 antibody (N-Term)

Catalog No. ABIN5518064

The Rabbit Polyclonal anti-Proteoglycan 4 antibody (ABIN5518064) specifically detects Proteoglycan 4 in WB. The antibody is reactive with Human samples.

Quick Overview for Proteoglycan 4 antibody (N-Term) (ABIN5518064)

Target: Proteoglycan 4 (PRG4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Proteoglycan 4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Proteoglycan 4 Antibody

Binding Specificity: N-Term

Purpose: PRG4 Antibody - N-terminal region

Sequence: KIKSSKNSAA NRELQKKLKV KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRG4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP78917-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Proteoglycan 4

Target: Proteoglycan 4 (PRG4)

Alternative Name: PRG4

Background:

Background Information: The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants.

Gene Name: proteoglycan 4

Alternative Symbols: MSF, SZP, CACP, HAPO, JCAP

Protein Name: proteoglycan 4

Molecular Weight: 93 kDa

Gene ID: 10216

NCBI Accession: NP_001121180

UniProt: J3KP74