IL-13 antibody (AA 36-146)

Catalog No. ABIN5518763

Cited in 5+ publications. This anti-IL-13 antibody is a Rabbit Polyclonal antibody detecting IL-13 in WB and IHC. Suitable for Human.

Quick Overview for IL-13 antibody (AA 36-146) (ABIN5518763)

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-IL-13 Antibody

Binding Specificity: AA 36-146

Purpose: Anti-IL13 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-IL13 Antibody (ABIN5518763). Tested in IHC, WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human IL13 recombinant protein (Position: P36-N146). Human IL13 shares 55.3% and 61.9% amino acid (aa) sequence identity with mouse and rat IL13, respectively.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-IL-13 antibody (ABIN5518763)

Liu, Wang, Cao, Liu, Zou, Li, Yang, Jiao: "Number 2 Feibi Recipe Reduces PM2.5-Induced Lung Injury in Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 3674145, (2018) (PubMed).

Zhu, Li, Wu, Lu, You, Li, Li, Yang, Duan: "Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice." in: Toxicology research, Vol. 5, Issue 1, pp. 268-277, (2018) (PubMed).

Li, Zhang, Qin, Bi, Liu, Li, Cai, Ma, Chan, Xie, Guan: "CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction." in: Oncotarget, Vol. 7, Issue 13, pp. 15525-38, (2017) (PubMed).

Wang, Liang, Wang, Zhu, Gong, Zhang, Li, Xia: "Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice." in: PLoS neglected tropical diseases, Vol. 9, Issue 1, pp. e0003434, (2016) (PubMed).

Long, Chen, Zhao, Rafaels, Mathias, Liang, Potee, Campbell, Zhang, Gao, Georas, Vercelli, Beaty, Ruczinski, Mathias, Barnes, Chen: "An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135360, (2016) (PubMed).

Target Details for IL-13

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Alternative Name: IL13

Background:

Synonyms: Interleukin-13,IL-13,IL13,NC30,

Tissue Specificity: Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.

Background: Interleukin 13 is a protein that in humans is encoded by the IL-13 gene. It is a kind of cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, which is an important mediator of allergic inflammation and disease. The IL-13 gene is mapped to 5q23-q31. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. Furthermore, this gene acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function.

Molecular Weight: 20 kDa

Gene ID: 3596

UniProt: P35225

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport