WHSC2 antibody (AA 251-279)

Catalog No. ABIN5531694

The Rabbit Polyclonal anti-WHSC2 antibody has been validated for WB. It is suitable to detect WHSC2 in samples from Human.

Quick Overview for WHSC2 antibody (AA 251-279) (ABIN5531694)

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WHSC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WHSC2 Antibody

Binding Specificity: AA 251-279

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for WHSC2

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Alternative Name: WHSC2

Background: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Molecular Weight: 57 kDa

Gene ID: 7469

UniProt: Q9H3P2

Pathways: Chromatin Binding