Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody

Details for Product No. ABIN1724801, Supplier: Log in to see
Antigen
  • BcDNA:SD07139
  • CG5874
  • Dmel\\CG5874
  • NELF
  • NELF-A
  • Whsc2
  • fi75f03
  • whsc2
  • wu:fi75f03
  • MGC85474
  • WHSC2
  • nelfa
  • nelf-a
  • p/okcl.15
  • Whsc2h
  • Negative elongation factor A
  • negative elongation factor complex member A
  • negative elongation factor complex member A L homeolog
  • negative elongation factor complex member A, Whsc2
  • Nelf-A
  • Nelfa
  • nelfa
  • nelfa.L
  • NELFA
Alternatives
anti-人 Wolf-Hirschhorn Syndrome Candidate 2 antibody for Western Blotting
Epitope
AA 280-511
11
11
9
8
7
4
3
3
2
2
1
1
1
1
1
Reactivity
Human
58
16
13
4
4
3
2
2
2
1
1
1
1
1
Host
Mouse
36
18
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
56
34
15
13
13
9
7
3
3
3
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human WHSC2 (AA 280-511) expressed in E. Coli.
Clone 6B11H8
Isotype IgG2b
Antigen
Alternative Name WHSC2 (WHSC2 Antibody Abstract)
Background This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. , ,
Molecular Weight 57.3 kDa
Gene ID 7469
HGNC 7469
Pathways Chromatin Binding
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
ELISA image for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (ABIN1724801) anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody
Flow Cytometry (FACS) image for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (ABIN1724801) anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (Image 2)
Immunocytochemistry (ICC) image for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (ABIN1724801) anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (Image 3)
Western Blotting (WB) image for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (ABIN1724801) anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (Image 4)
Western Blotting (WB) image for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (ABIN1724801) anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (Image 5)
Western Blotting (WB) image for anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (ABIN1724801) anti-Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2) (AA 280-511) antibody (Image 6)
Product cited in: Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, 2012 (PubMed).

Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." in: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, 2009 (PubMed).

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