MLL3 antibody (N-Term)

Catalog No. ABIN5532940

This anti-MLL3 antibody is a Rabbit Polyclonal antibody detecting MLL3 in IHC (p). Suitable for Human.

Quick Overview for MLL3 antibody (N-Term) (ABIN5532940)

Target: MLL3 (KMT2C) (Histone-lysine N-methyltransferase 2C (KMT2C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MLL3 Antibody

Binding Specificity: AA 1142-1175, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1175 amino acids from the N-terminal region of human MLL3.

Isotype: Ig Fraction

Application Details

Application Notes: For IHC-P starting dilution is: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MLL3

Target: MLL3 (KMT2C) (Histone-lysine N-methyltransferase 2C (KMT2C))

Alternative Name: MLL3

Background: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

Molecular Weight: 541 kDa

Gene ID: 58508

UniProt: Q8NEZ4

Pathways: Warburg Effect