NEDD4-2 antibody (AA 576-604)

Catalog No. ABIN5537199

Product Details anti-NEDD4-2 Antibody

Target: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Binding Specificity: AA 576-604

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEDD4-2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NEDD4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-604 amino acids from the Central region of human NEDD4L.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NEDD4-2

Target: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Alternative Name: NEDD4L (NEDD4L Products)

Synonyms: NEDD4-2 antibody, NEDD4.2 antibody, RSP5 antibody, hNEDD4-2 antibody, nedd4 antibody, nedd4-2 antibody, NEDD4 antibody, Nedd4-2 antibody, 1300012C07Rik antibody, Nedd4b antibody, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase antibody, NEDD4L antibody, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog antibody, neural precursor cell expressed, developmentally down-regulated gene 4-like antibody, NEDD4L antibody, LOC776799 antibody, nedd4l.S antibody, Nedd4l antibody

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.

Molecular Weight: 112 kDa

Gene ID: 23327

UniProt: Q96PU5

Pathways: Negative Regulation of Transporter Activity