SFTPB antibody (AA 129-158)

Catalog No. ABIN5537428

Product Details anti-SFTPB Antibody

Target: SFTPB (Surfactant Protein B (SFTPB))

Binding Specificity: AA 129-158

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SFTPB antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SFTPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the Central region of human SFTPB.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SFTPB

Target: SFTPB (Surfactant Protein B (SFTPB))

Alternative Name: SFTPB (SFTPB Products)

Synonyms: PSP-B antibody, SFTB3 antibody, SFTP3 antibody, SMDP1 antibody, SP-B antibody, AI562151 antibody, SF-B antibody, Sftp-3 antibody, Sftp3 antibody, Sp-b antibody, SFTPB antibody, sftpb antibody, xSP-B antibody, surfactant protein B antibody, surfactant associated protein B antibody, surfactant, pulmonary-associated protein B L homeolog antibody, SFTPB antibody, Sftpb antibody, sftpb.L antibody

Background: SFTPB is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90 % lipids and 10 % proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Molecular Weight: 42 kDa

Gene ID: 6439

UniProt: P07988