GAP43 antibody (C-Term)

Catalog No. ABIN5540032

The Chicken Polyclonal anti-GAP43 antibody (ABIN5540032) specifically detects GAP43 in WB, IF and ICC. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for GAP43 antibody (C-Term) (ABIN5540032)

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Reactivity: Human, Rat, Mouse

Host: Chicken

Clonality: Polyclonal

Conjugate: This GAP43 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-GAP43 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects GAP43.

Purification: Ig Fraction

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region of the rat GAP43 sequence

Application Details

Application Notes: Western blot: 1/2000. Immunoflourescence: 1/500.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 10 mM Sodium azide

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for GAP43

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Alternative Name: gap43

Background: GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser 41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).

UniProt: P07936