THBD
Reactivity: Human
WB, FACS, IF
Host: Rabbit
Polyclonal
RB56919
unconjugated
Application Notes
ELISA.
Restrictions
For Research Use only
Format
Liquid
Buffer
0.22 μm Sterile-filtered PBS. Carrier and preservative free.
Preservative
Azide free
Storage
4 °C
Storage Comment
Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Expiry Date
12 months
Target
Thrombomodulin (THBD)
Alternative Name
cd141,thbd
Background
CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.