PD-1 antibody

Catalog No. ABIN5540157

The Mouse Monoclonal anti-PD-1 antibody is suitable to detect PD-1 in samples from Human. It has been validated for WB and EIA.

Quick Overview for PD-1 antibody (ABIN5540157)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PD-1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 1C4

Product Details anti-PD-1 Antibody

Specificity: Reactive with recombinant Human Programmed Cell Death-1 (PD-1). Reactivity with natural PD-1 has not been evaluated.

Purification: Affinity Chromatography on Protein G

Immunogen: 40kDa recombinant Human Programmed Cell Death-1 (PD-1).

Isotype: IgG1

Application Details

Application Notes: Indirect ELISA. Western Blot.

Restrictions: For Research Use only

Handling

Buffer: 0.01M PBS, pH 7.2 without preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: cd279,pd1

Background: Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages. When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell's activation and effector function are attenuated. Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer's immune-evasion, autoimmunity, and Listeria monocytogenes infection.

UniProt: Q15116

Pathways: Cancer Immune Checkpoints