CX3CR1 antibody

Catalog No. ABIN5540227

The Mouse Monoclonal anti-CX3CR1 antibody (Clone 1G4) (ABIN5540227) specifically detects CX3CR1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for CX3CR1 antibody (ABIN5540227)

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CX3CR1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1G4

Product Details anti-CX3CR1 Antibody

Specificity: This antibody detetcs CX3C Receptor 1. The specificity of the antibody was verified by flow cytometry with cells expressing the recombinant protein. The epitope has not been further characterized.

Purification: Affinity Chromatography on Protein G

Immunogen: DNA vaccine

Isotype: IgG2b

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 2 μg/mL (1/100), pretreatment with proteinase K required. Suggested Positive Control: Human brain cortex.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL BSA

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CX3CR1

Target: CX3CR1 (Chemokine (C-X3-C Motif) Receptor 1 (CX3CR1))

Alternative Name: cx3cr1,gpr13

Background: G-protein coupled receptor 1 3 (GPR13) is a 355 amino acid protein that belongs to the G - protein coupled receptor 1 family. Biologically, the fractalkine (CX3CL1) to fractalkine receptor (CX3CR1) interactions play an important role in macrophage recruitment to target organs such as the brain, the intestine, the liver or the lungs. Accordingly, expression of the CX3CR1 has been described in inflammation - and tumor - associated macrophages, intestinal lamina propia macrophages, and B cells. Also, CX3CR1 mediates adhesive and migratory functions and acts as a coreceptor with CD4 for HIV - 1 virus gp160 envelope protein.

UniProt: P49238

Pathways: Cellular Response to Molecule of Bacterial Origin