IL13 Receptor alpha 1 antibody (Extracellular Domain)

Catalog No. ABIN5540414

This Mouse Monoclonal antibody specifically detects IL13 Receptor alpha 1 in IF, ICC, FACS and EIA. It exhibits reactivity toward Human.

Quick Overview for IL13 Receptor alpha 1 antibody (Extracellular Domain) (ABIN5540414)

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL13 Receptor alpha 1 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: GM1E7

Product Details anti-IL13 Receptor alpha 1 Antibody

Binding Specificity: Extracellular Domain

Specificity: Recognizes IL13 Receptor (IL13-R).

Purification: Affinity Chromatography on Protein G

Immunogen: Genetic immunization with cDNA encoding Human IL13-R alpha 1 (extracellular domain). Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.

Isotype: IgG1

Application Details

Application Notes: Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow cytometry: 1.2 μg/10 6 cells. Immunofluorescence: 1 μg/10 Specific inhibition of IL-13-dependent proliferation of TF-1 cells by GM-1E7 (See Figure.3).

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2 without preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for IL13 Receptor alpha 1

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Alternative Name: cd213a1,il13ra1

Background: Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Ra1 together with IL-4Ra forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation

UniProt: P78552

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response