SPTAN1 antibody

Catalog No. ABIN5540660

This Mouse Monoclonal antibody specifically detects SPTAN1 in WB, ICC and IF. It exhibits reactivity toward Human, Rat and Cow.

Quick Overview for SPTAN1 antibody (ABIN5540660)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reactivity: Human, Rat, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This SPTAN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 3D7

Product Details anti-SPTAN1 Antibody

Specificity: Specific for the ~240 k alpha II Spectrin protein.

Purification: Affinity Chromatography

Immunogen: Recombinant construct containing the seventh, eighth and ninth repeats of human alpha II spectrin expressed in and purified from E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1/3000. Immunofluorescence: 1/500.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS Preservatives: 10 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Alternative Name: spectrin alpha chain (brain),sptan1

Background: The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).

UniProt: P07751

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization